DAVOUST-NATAF Nathalie

• Grade/Statut : PU
• Établissement : ENS de Lyon
• Bâtiment : M4
• Étage : 1er
• Bureau : M4 104
• E-mail : nathalie.davoust-nataf@ens-lyon.fr
• Laboratoire : LBMC

Thème(s) de recherche

• Caracterization of the ribosome interactome of murine macrophages upon acute inflammatory stimulation.
• Glial cells functions in neuro-inflammatory processes.

• Although transcriptional regulation has been at the forefront of studies of innate immunity, the role of post-transcriptional regulation (such as alternative splicing, mRNA decay or translational control) in controlling gene expression in macrophages and other innate immune cells is emerging as an important regulatory layer. Among these, regulation of mRNA translation allows for rapid and reversible modulation of gene expression but its precise role and control mechanisms in the inflammatory response remain poorly understood. My current ressearch aims at characterizing the role of ribosomes and mRNA translation in regulating the inflammatory response. In particular, we propose to identify the complete set of of ribosome associated proteins (RAPs) and to determine their role in the context of “specialized ribosomes” with specific regulatory activities using a novel transgenic mouse model expressing Flag-Tagged ribosomes.