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Outils personnels

Département de biologie

UE Comparative Genomics

Responsables : Celine Brochier-Armanet (PU, UCBL), Marie Sémon (MCU, ENS Lyon)

6 ECTS, 36h de cours





This course will introduce students to comparative genomics. Comparative biology has always been a way to understand living systems. Today, this is done with big data analyses (genomes, transcriptomes, epigenomes etc) . Hence comparative genomics is used in many fields. Whole genome comparisons are revolutionizing whole areas of biology, by allowing to approach in a global manner the mechanisms behind the diversity and evolution of genomes, cellular processes, phenotypes, populations and species. We will focus on the main current challenges, linked to the development of genomics in fields as varied as origin of life, human evolution and medicine, ecology, and biotechnology. Topics covered include methods of genome analysis, mechanisms responsible for the evolution of prokaryotic and eukaryotic genomes, phylogenomics, reconstruction of ancestral genomes, metagenomics, paleogenomics, population genomics, personal and medical genomics and adaptive genomics. This course involves specialists of international reputation in the field of genome analysis, who will interact strongly with students during conferences and round tables.



Content may vary according to years

  • Ancient genomes

  • Tree of life

  • Eukaryote genome evolution

  • Sexual cells / sex determination

  • Transposable elements / mobile elements

  • Genomic evolution of past and present human populations

  • Domestication

  • Metagenomics / Microbiome

  • Adaptation / Speciation

  • Developmental genomics

  • Genomes and life history traits




Every day, 2 speakers will present two aspects of the same subject. Lectures will start by a broad introduction, and raise up to the most recent research developments. A particular attention will be given to the synergy between the presentations so that to enrich the discussion afterwards. A round table will take place at the end of the day, offering the students an opportunity to interact freely with these specialists of the field.



Note: Some of the objectives will be worked on more deeply depending on the exact list of topics covered this year.

  • Introduction to current topics in molecular evolution, and more broadly comparative genomics.

  • Learning how to grasp a new theme rapidely, and make links with other themes.

  • Learn how to write a synthesis based on different presentation.

  • Be critical on modelling and their results (statistics, possible bias and confunding effects etc)

  • Understand the main ideas behind mathematical models in comparative genomics.

  • Ask questions in English, interact in a positive manner with speakers and fellow students. Work in groups and in a constructive manner, so that even shy student may express themselves.

  • Start to build up a network, since half the audience do not come from ENS de Lyon, and some from other countries (this may not apply in corona times).



None. This course naturally follows the “UE Evolution Moléculaire” in master 1, but it is not compulsory.



Contrôle continu 40%; Contrôle terminal 60%

Oral student presentations and participation to the round table discussions as well as a final written exam.